The number of cases shot up by 2,560 to 74,860, it said.
A total of 996 patients were discharged from hospitals in the day, taking the tally of the recovered cases to 32,329 so far, a statement said.
The number of active cases in the state now stands at 39,935, it said, adding that a total of 4,97,276 samples have been tested so far.
“Of the 122 deaths, 60 fatalities were reported from the Mumbai Metropolitan Region (MMR), including 49 from Mumbai alone,” the statement said.
Pune city, another major hotspot, reported 19 more deaths in a day, it added.
Mumbai now accounts for 43,492 COVID-19 cases of the total 74,860 cases in the state with 1,417 deaths.
The MMR accounts for 56,794 coronavirus cases and 1,742 deaths, it stated.
The total number of cases in Pune Municipal Corporation limits now stands at 7,390 with 343 deaths, while the Aurangabad city has reported 1,609 cases and 83 fatalities, it said.
The case count for Solapur city stood at 973 and fatalities at 80.
Malegaon, a hotspot in Nashik district, did not report any fresh case or death on Wednesday.
As of Tuesday, it had reported 762 cases and 58 deaths, it said.
The tally of cases in Nagpur city is 596 with 11 deaths. 601 cases with 27 fatalities have been recorded in Akola city till date.
The number of containment zones in Maharashtra now stands at 3,661.
The COVID 19 tally in Maharashtra: total cases 74,860, recoveries 32,329, deaths 2,587, active cases 39,935 and people tested 4,97,276.