The country has officially logged 1,809,109 cases of Covid-19, the tracker set up by the Baltimore-based university showed at 8:30pm (0030 GMT Tuesday).
The death toll and number of cases in the United States are by far the worst in the world.
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The virus has killed at least 373, 439 people around the world since it appeared in late 2019 in China, according to a report compiled by AFP from official sources.
In the United States, states have begun relaxing confinement measures intended to slow the spread of the virus in varying degrees.
But several major US cities have issued curfews in the face of violent protests sparked by the death in Minneapolis police custody of George Floyd, an unarmed black man who was killed last week after a white officer knelt on his neck for nine minutes.